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病态肥胖的南印度患者中胆结石和胆总管结石的患病率以及袖状胃切除术、胃旁路手术和迷你胃旁路手术后胆石症的进一步发展

Prevalence of Cholelithiasis and Choledocholithiasis in Morbidly Obese South Indian Patients and the Further Development of Biliary Calculus Disease After Sleeve Gastrectomy, Gastric Bypass and Mini Gastric Bypass.

作者信息

Mishra Tapas, Lakshmi Kona Kumari, Peddi Kiran Kumar

机构信息

Department of Minimal Access and Bariatric Surgery, Global Hospitals, Hyderabad, India.

Department of Gastroenterology, Global Hospitals, Hyderabad, India.

出版信息

Obes Surg. 2016 Oct;26(10):2411-7. doi: 10.1007/s11695-016-2113-4.

DOI:10.1007/s11695-016-2113-4
PMID:26910024
Abstract

BACKGROUND

Evaluation of the prevalance of cholelithiasis, choledocholithiasis and there management after sleeve gastrectomy, gastric bypass and mini gastric bypass in Indian bariatric patients.

METHODS

We did a retrospective analysis of our bariatric patient from January 2007 to December 2013 (n = 1397), for prevalence of cholelithiasis and choledocholithiasis. We did synchronous cholecystectomy in all patients planned for bariatric surgery found to have cholelithiasis on USG. Post-operatively, we followed all the patients with gallbladder in situ for minimum of 18-88 months (mean -32.4) and reviewed data for subsequent development of cholelithiasis/choledocholithiasis. Only those patients who were symptomatic underwent intervention.

RESULTS

Prevalence of cholelithiasis and choledocholithiasis in our study was 21.76 and 9.63 %, respectively. The incidence of post-bariatric surgery development of cholelithiasis was 10.53 %; individually, it was 8.42 % in LSG group, 13.4 % in LRYGB group and 12.7 % in MGB patients. The incidence of symptomatic cholelithiasis requiring surgery was 1.94 % after LSG, 4.54 % after LRYGB and 4.25 % after MGB. Post-surgery, six patients developed choledocholithiasis. In our post-bariatric group, the 33 patients who developed symptomatic stones had percentage total weight loss of 30.99 + 4.1 (P < 0.001). The average time period for readmission of symptomatic patient was 11.26 + 2.67 months.

CONCLUSIONS

We recommend routine synchronous cholecystectomy with bariatric procedure. In spite of synchronous cholecystectomy, incidence of cholelithiasis in our post-bariatric patient is 10.53 % of which up to one third were symptomatic and required surgery, and incidence of choledocholithiasis is comparable to that of general population.

摘要

背景

评估印度肥胖症患者在接受袖状胃切除术、胃旁路手术和迷你胃旁路手术后胆结石、胆总管结石的患病率及其治疗情况。

方法

我们对2007年1月至2013年12月期间的肥胖症患者(n = 1397例)进行了回顾性分析,以了解胆结石和胆总管结石的患病率。对于所有计划接受肥胖症手术且经超声检查发现有胆结石的患者,我们实施了同期胆囊切除术。术后,我们对所有保留胆囊的患者进行了至少18至88个月(平均32.4个月)的随访,并复查了胆结石/胆总管结石后续发生情况的数据。只有出现症状的患者才接受干预治疗。

结果

在我们的研究中,胆结石和胆总管结石的患病率分别为21.76%和9.63%。肥胖症手术后胆结石的发生率为10.53%;具体而言,袖状胃切除术组为8.42%,腹腔镜Roux-en-Y胃旁路手术组为13.4%,迷你胃旁路手术患者为12.7%。需要手术治疗的有症状胆结石的发生率在袖状胃切除术后为1.94%,腹腔镜Roux-en-Y胃旁路手术后为4.54%,迷你胃旁路手术后为4.25%。术后,有6例患者发生了胆总管结石。在我们的肥胖症手术后组中,33例出现有症状结石的患者总体重减轻百分比为30.99±4.1(P < 0.001)。有症状患者再次入院的平均时间为11.26±2.67个月。

结论

我们建议肥胖症手术同时常规进行同期胆囊切除术。尽管进行了同期胆囊切除术,但我们的肥胖症手术后患者中胆结石的发生率仍为10.53%,其中多达三分之一有症状且需要手术治疗,胆总管结石的发生率与普通人群相当。

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