肝活检：标本大小在慢性病毒性肝炎诊断和分期中的重要性
LIVER BIOPSY: IMPORTANCE OF SPECIMEN SIZE IN THE DIAGNOSIS AND STAGING OF CHRONIC VIRAL HEPATITIS.
作者信息
Coral Gabriela P, Antunes Aline Dal Pozzo, Serafini Ana Paula Almeida, Araujo Fernanda B, Mattos Angelo Alves de
机构信息
Universidade Federal de Ciências da Saúde de Porto Alegre, Brazil.
Irmandade Santa Casa de Misericórdia de Porto Alegre, Brazil.
出版信息
Rev Inst Med Trop Sao Paulo. 2016;58:10. doi: 10.1590/S1678-9946201658010. Epub 2016 Feb 23.
UNLABELLED
Liver biopsy is the gold standard method for the grading and staging of chronic viral hepatitis, but optimal biopsy specimen size remains controversial. The aim of this study was to evaluate the quality of liver specimen (number of portal tracts) and to evaluate the impact of the number of portal tracts in the staging of chronic hepatitis.
MATERIAL AND METHODS
468 liver biopsies from consecutive patients with hepatitis C virus and hepatitis B virus infection from 2009 to 2010 were evaluated.
RESULTS
The length of fragment was less than 10 mm in 43 cases (9.3%), between 10 and 14 mm in 114 (24.3%), and ≥ 15 mm in 311 (64.4%); of these, in 39 (8.3%) cases were ≥ 20 mm. The mean representation of portal tracts was 17.6 ± 2.1 (5-40); in specimens ≥ 15 mm the mean portal tract was 13.5 ± 4.7 and in cases ≤ 15 mm was 11.4 ± 5.0 (p = 0.002). Cases with less than 11 portal tracts were associated with F3, and cases with 11 or more portal tracts with F2 (p = 0.001).
CONCLUSION
this study demonstrated the good quality of liver biopsy and a relationship between the macroscopic size of the fragment and the number of portal tracts.
未标注
肝活检是慢性病毒性肝炎分级和分期的金标准方法，但最佳活检标本大小仍存在争议。本研究的目的是评估肝标本质量（门管区数量）并评估门管区数量在慢性肝炎分期中的影响。
材料与方法
对2009年至2010年连续的468例丙型肝炎病毒和乙型肝炎病毒感染患者的肝活检进行评估。
结果
标本长度小于10mm的有43例（9.3%），10至14mm的有114例（24.3%），≥15mm的有311例（64.4%）；其中，≥20mm的有39例（8.3%）。门管区的平均数量为17.6±2.1（5 - 40）；在≥15mm的标本中，门管区平均数量为13.5±4.7，在≤15mm的标本中为11.4±5.0（p = 0.002）。门管区少于11个的病例与F3相关，门管区为11个或更多的病例与F2相关（p = 0.001）。
结论
本研究证明了肝活检的良好质量以及标本宏观大小与门管区数量之间的关系。
Zotero 插件