Vinge Lotte, Andersen Henning
Aarhus University Hospital, Department of Neurology, Noerrebrogade 44, building 10, 3rd Floor, 8000, Aarhus, Denmark.
Muscle Nerve. 2016 Oct;54(4):709-14. doi: 10.1002/mus.25084. Epub 2016 Aug 19.
Dynamometry is increasingly used as an objective measurement of muscle strength in neurological diseases. No study has applied dynamometry in untreated newly diagnosed patients with myasthenia gravis (MG).
Isometric muscle strength at the shoulder, knee, and ankle was determined in 21 MG patients before and after initial anti-myasthenic treatment. Isometric strength was compared with MG evaluation scales.
Muscle strength was reduced for knee extensors and shoulder abductors but normal for ankle extensors. Isometric muscle strength did not correlate significantly with manual muscle testing (MG Composite). Dynamometry revealed improved muscle strength of up to 50% (median 17%; range -1.8-49.8) despite no change in the MG Composite score.
Dynamometry appears to be a more sensitive method of identifying changes in limb strength than MG evaluation scales. This supports the use of dynamometry in MG patients, especially for evaluation of the effect of anti-myasthenic treatment. Muscle Nerve 54: 709-714, 2016.
测力计越来越多地被用作神经系统疾病中肌肉力量的客观测量方法。尚无研究将测力计应用于未经治疗的新诊断重症肌无力（MG）患者。
在21例MG患者初始抗重症肌无力治疗前后，测定其肩部、膝部和踝部的等长肌肉力量。将等长力量与MG评估量表进行比较。
膝伸肌和肩外展肌的肌肉力量降低，但踝伸肌正常。等长肌肉力量与徒手肌力测试（MG综合评分）无显著相关性。尽管MG综合评分没有变化，但测力计显示肌肉力量提高了50%（中位数为17%；范围为-1.8 - 49.8）。
与MG评估量表相比，测力计似乎是一种更敏感的识别肢体力量变化的方法。这支持在MG患者中使用测力计，特别是用于评估抗重症肌无力治疗的效果。《肌肉与神经》54: 709 - 714, 2016。
