Jordan Berit, Schweden Tabea L K, Mehl Theresa, Menge Uwe, Zierz Stephan
Department of Neurology, Martin-Luther-University Halle, Ernst-Grube-Strasse 40, 06097, Halle/Saale, Germany.
Institute of Psychology, Martin-Luther-University Halle, Halle/Saale, Germany.
Muscle Nerve. 2017 Sep;56(3):449-457. doi: 10.1002/mus.25540. Epub 2017 Mar 23.
Cognitive fatigue has frequently been reported in myasthenia gravis (MG). However, objective assessment of cognitive fatigability has never been evaluated.
Thirty-three MG patients with stable generalized disease and 17 healthy controls underwent a test battery including repeated testing of attention and concentration (d2-R) and Paced Auditory Serial Addition Test. Fatigability was based on calculation of linear trend (LT) reflecting dynamic performance within subsequent constant time intervals. Additionally, fatigue questionnaires were used.
MG patients showed a negative LT in second d2-R testing, indicating cognitive fatigability. This finding significantly differed from stable cognitive performance in controls (P < 0.05). Results of Paced Auditory Serial Addition Test testing did not differ between groups. Self-assessed fatigue was significantly higher in MG patients compared with controls (P < 0.001), but did not correlate with LT.
LT quantifies cognitive fatigability as an objective measurement of performance decline in MG patients. Self-assessed cognitive fatigue is not correlated with objective findings. Muscle Nerve 56: 449-457, 2017.
重症肌无力（MG）患者经常出现认知疲劳。然而，从未对认知疲劳能力进行过客观评估。
33例病情稳定的全身型MG患者和17名健康对照者接受了一系列测试，包括对注意力和专注力的重复测试（d2-R）以及听觉连续加法测试。疲劳能力基于线性趋势（LT）的计算，该趋势反映了在随后恒定时间间隔内的动态表现。此外，还使用了疲劳问卷。
MG患者在第二次d2-R测试中显示出负向LT，表明存在认知疲劳。这一发现与对照组稳定的认知表现有显著差异（P < 0.05）。听觉连续加法测试结果在两组之间没有差异。MG患者自我评估的疲劳程度明显高于对照组（P < 0.001），但与LT无关。
LT将认知疲劳量化为MG患者表现下降的一种客观测量方法。自我评估的认知疲劳与客观结果无关。《肌肉与神经》56: 449 - 457, 2017。
