Aarli J A, Mørk S J, Myrseth E, Larsen J L
Department of Neurology, Haukeland Hospital, Bergen, Norway.
Eur Neurol. 1989;29(6):312-6. doi: 10.1159/000116437.
A 63-year-old man died of a brain tumor 29 years after onset of multiple sclerosis (MS). The MS diagnosis was based upon clinical evidence of two brain stem lesions, separate in time, retinal periphlebitis, a fluctuating course of the disease, and supported by the observation of definite cognitive impairment at the age of 41 years, and an increased number of lymphocytes in the cerebrospinal fluid which normalized during gradual recovery. The MS diagnosis was confirmed at autopsy, which also revealed a glioblastoma developing adjacent to typical MS plaques.
一名63岁男性在多发性硬化症（MS）发病29年后死于脑肿瘤。MS的诊断基于两个脑干病变的临床证据，病变在时间上相互独立，伴有视网膜静脉周围炎，疾病呈波动病程，且41岁时出现明确的认知障碍，脑脊液中淋巴细胞数量增加，在逐渐恢复过程中恢复正常，这些均支持MS的诊断。尸检证实了MS的诊断，同时还发现一个胶质母细胞瘤在典型的MS斑块附近形成。
