1 Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, F-34295 Montpellier, France 2 Institute for Neuroscience of Montpellier, INSERM U1051 (Plasticity of Central Nervous System, Human Stem Cells and Glial Tumors research group), Saint Eloi Hospital, Montpellier University Medical Center, F-34091 Montpellier, France
3 Départements d'Etudes Cognitives, Ecole Normale Supérieure, F-75005 Paris, France 4 Faculté des Sciences Fondamentales et Biomédicales, Université Paris Descartes, F-75006 Paris, France.
Brain. 2016 Mar;139(Pt 3):829-44. doi: 10.1093/brain/awv394. Epub 2016 Feb 8.
It is increasingly acknowledged that the brain is highly plastic. However, the anatomic factors governing the potential for neuroplasticity have hardly been investigated. To bridge this knowledge gap, we generated a probabilistic atlas of functional plasticity derived from both anatomic magnetic resonance imaging results and intraoperative mapping data on 231 patients having undergone surgery for diffuse, low-grade glioma. The atlas includes detailed level of confidence information and is supplemented with a series of comprehensive, connectivity-based cluster analyses. Our results show that cortical plasticity is generally high in the cortex (except in primary unimodal areas and in a small set of neural hubs) and rather low in connective tracts (especially associative and projection tracts). The atlas sheds new light on the topological organization of critical neural systems and may also be useful in predicting the likelihood of recovery (as a function of lesion topology) in various neuropathological conditions-a crucial factor in improving the care of brain-damaged patients.
人们越来越认识到大脑具有高度的可塑性。然而，控制神经可塑性潜力的解剖因素几乎没有得到研究。为了弥补这一知识空白，我们基于 231 名接受弥漫性低级别神经胶质瘤手术治疗的患者的解剖磁共振成像结果和术中映射数据，生成了一个功能可塑性概率图谱。该图谱包含详细的置信度信息，并辅以一系列全面的基于连接性的聚类分析。我们的研究结果表明，皮质的可塑性通常很高（除了在初级单一模态区域和一小部分神经中枢），而在连接束中则相当低（特别是联合和投射束）。该图谱为关键神经系统的拓扑结构提供了新的认识，也可能有助于预测各种神经病理学条件下（作为病变拓扑的函数）的恢复可能性，这是改善脑损伤患者护理的关键因素。
