Bégin R, Cantin A, Massé S
Unité de recherche pulmonaire, CHU Sherbrooke, Québec, Canada.
Eur Respir J. 1989 Nov;2(10):988-1001.
Recent investigations of the fundamental mechanisms of the mineral dust diseases have substantially increased our understanding of the pathogenesis of the pneumoconioses. In all the mineral dust pneumoconioses, the initial early lung lesion is a fibrosing macrophagic alveolitis. The additional contribution of other lung cell populations is currently under investigation and may identify specific processes for each of the pneumoconioses. Clinical investigations have also progressed with new tools such as Gallium-67 lung scanning, bronchoalveolar lavage analyses, and CT scanning of the thorax; their established values are reviewed in this paper, and areas where progress is needed are considered. The clinical progress in the mineral dust diseases is clearly linked to the basic understanding of the mechanisms of these diseases.
近期对矿物粉尘疾病基本机制的研究极大地增进了我们对尘肺病发病机制的理解。在所有矿物粉尘所致的尘肺病中，最初的早期肺部病变是纤维化巨噬细胞肺泡炎。目前正在研究其他肺细胞群的额外作用，这可能会明确每种尘肺病的具体发病过程。临床研究也借助镓 - 67肺部扫描、支气管肺泡灌洗分析和胸部CT扫描等新工具取得了进展；本文对这些工具已确定的价值进行了综述，并探讨了仍需取得进展的领域。矿物粉尘疾病的临床进展显然与对这些疾病机制的基本理解相关联。
