Liu Jing-Yi, Chen Xiao-Xin, Tang Sydney Chi-Wai, Sze Stephen Cho-Wing, Feng Yi-Bin, Lee Kai-Fai, Zhang Kalin Yan-Bo
School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Hong Kong, People's Republic of China.
Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Hong Kong, People's Republic of China.
Chin Med. 2016 Feb 24;11:6. doi: 10.1186/s13020-016-0075-z. eCollection 2016.
Diabetic nephropathy (DN) is a severe micro vascular complication accompanying diabetes mellitus that affects millions of people worldwide. End-stage renal disease occurs in nearly half of all DN patients, resulting in large medical costs and lost productivity. The course of DN progression is complicated, and effective and safe therapeutic strategies are desired. While the complex nature of DN renders medicines with a single therapeutic target less efficacious, Chinese medicine, with its holistic view targeting the whole system of the patient, has exhibited efficacy for DN management. This review aims to describe the experimental evidence for Chinese medicines in DN management, with an emphasis on the underlying mechanisms, and to discuss the combined use of herbs and drugs in DN treatment.
糖尿病肾病（DN）是糖尿病伴随的一种严重微血管并发症，影响着全球数百万人。近一半的糖尿病肾病患者会发展为终末期肾病，导致巨额医疗费用和生产力损失。糖尿病肾病的进展过程复杂，需要有效且安全的治疗策略。鉴于糖尿病肾病的复杂性使得单一治疗靶点的药物疗效欠佳，而中医以其针对患者整个系统的整体观，在糖尿病肾病管理方面已显示出疗效。本综述旨在描述中药在糖尿病肾病管理中的实验证据，重点是其潜在机制，并讨论中药与西药在糖尿病肾病治疗中的联合应用。
