Shafiee Gita, Khamseh Mohammad E, Rezaei Nader, Aghili Rokhsareh, Malek Mojtaba
Endocrine Research Center (Firouzgar), Institute of Endocrinology and Metabolism, Tehran University of Medical Sciences, Karimkhan St, Tehran 1593748711, Iran.
J Diabetes Metab Disord. 2013 Apr 24;12(1):15. doi: 10.1186/2251-6581-12-15.
Type 2 diabetes mellitus is increasing worldwide with an alarming rate. It is associated with the development of various chronic complications. The aim of this study was to explore the alteration of pulmonary function, and its association with renal complications in people with type 2 diabetes mellitus.
This cross-sectional study was conducted on three groups; 40 diabetic subjects without nephropathy (urinary albumin<30 mg/day), 40 subjects with nephropathy (urinary albumin≥30 mg/day), and 40 healthy subjects as the control group. The subjects with nephropathy were divided into those with microalbuminuria (urinary albumin=30-300 mg/day) and those with macroalbuminuria (urinary albumin>300 mg/day) .Diabetic subjects were matched to the control group in terms of age, sex, and BMI. Pulmonary function tests were performed and the results were compared between groups.
Forced vital capacity (FVC; % predicted), forced expiratory volume in 1 second (FEV1; % predicted), and peak expiratory flow (PEF; % predicted) were significantly lower in subjects with diabetic nephropathy compared to the healthy controls (P<0.05). Meanwhile, in diabetic subjects, FVC and FEV1 were lower in those with diabetic nephropathy compared to those with normal albumin excretion (P<0.05). On the other hand, FEV1/FVC was significantly higher in diabetic people with nephropathy.Furthermore, a significant difference was observed between FVC and FEV1 in diabetic people with microalbuminuria compared to those with macroalbuminuria.
This study showed that the pulmonary function was impaired in people with Diabetes. The progression of diabetic nephropathy to more advanced stages was also associated with more impairment of pulmonary function.
2型糖尿病在全球范围内正以惊人的速度增长。它与各种慢性并发症的发生有关。本研究的目的是探讨2型糖尿病患者肺功能的变化及其与肾脏并发症的关系。
本横断面研究对三组人群进行了调查；40名无肾病的糖尿病患者（尿白蛋白<30mg/天），40名患有肾病的患者（尿白蛋白≥30mg/天），以及40名健康受试者作为对照组。患有肾病的受试者被分为微量白蛋白尿组（尿白蛋白=30-300mg/天）和大量白蛋白尿组（尿白蛋白>300mg/天）。糖尿病患者在年龄、性别和BMI方面与对照组相匹配。进行了肺功能测试，并对各组结果进行了比较。
与健康对照组相比，糖尿病肾病患者的用力肺活量（FVC；预测值%）、第1秒用力呼气量（FEV1；预测值%）和呼气峰值流速（PEF；预测值%）显著降低（P<0.05）。同时,在糖尿病患者中，与尿白蛋白排泄正常的患者相比，糖尿病肾病患者的FVC和FEV1较低（P<0.05）。另一方面，患有肾病的糖尿病患者的FEV1/FVC显著更高。此外，与大量白蛋白尿患者相比，微量白蛋白尿糖尿病患者的FVC和FEV1存在显著差异。
本研究表明糖尿病患者的肺功能受损。糖尿病肾病进展到更晚期阶段也与肺功能的更多损害有关。
