Depla A C
Department of Gastroenterology and Hepatology, St. Antonius Hospital, Nieuwegein, The Netherlands.
Digestion. 1989;44 Suppl 1:63-7. doi: 10.1159/000200105.
A case is described with pathological gastro-oesophageal reflux and nighttime bronchial asthma. Treatment with omeprazole resulted not only in improvement of gastro-oesophageal reflux but also in alleviation of asthmatic symptoms and increases in expiratory peak flow values. The possible pathophysiological mechanisms whereby gastro-oesophageal reflux may induce or aggravate asthmatic symptoms are discussed. At present it is not yet possible to predict which patients with bronchial asthma will benefit from antireflux therapy with respect to their pulmonary condition, but such treatment is warranted in all patients with bronchial asthma and proven pathological gastro-oesophageal reflux.
本文描述了一例伴有病理性胃食管反流和夜间支气管哮喘的病例。使用奥美拉唑治疗不仅改善了胃食管反流，还缓解了哮喘症状，并提高了呼气峰流速值。文中讨论了胃食管反流可能诱发或加重哮喘症状的潜在病理生理机制。目前尚无法预测哪些支气管哮喘患者的肺部状况会从抗反流治疗中获益，但对于所有患有支气管哮喘且已证实存在病理性胃食管反流的患者，这种治疗是必要的。
