小鼠肾素编码基因Ren-1d及其上游区域的核苷酸序列。

The nucleotide sequence of a mouse renin-encoding gene, Ren-1d, and its upstream region.

作者信息

Burt D W, Mullins L J, George H, Smith G, Brooks J, Pioli D, Brammar W J

机构信息

Department of Biochemistry, University of Leicester, U.K.

出版信息

Gene. 1989 Dec 7;84(1):91-104. doi: 10.1016/0378-1119(89)90143-1.

DOI:10.1016/0378-1119(89)90143-1

PMID:2691339

Abstract

The renin-encoding genes have been cloned from high (Ren-1d, Ren-2d)- and low (Ren-1c)-renin-producing strains of mice (DBA/2J and C57BL/10). Each of the genes is approx. 9.6 kb in length and consists of nine exons and eight introns. The entire nucleotide sequence of the Ren-1d gene has been determined and the 5'-flanking regions of the three genes, Ren-1c, Ren-1d and Ren-2d, have been compared. The significance of several potential regulatory signals found in the DNA is discussed.

摘要

肾素编码基因已从小鼠（DBA/2J和C57BL/10）的高肾素产生株（Ren-1d、Ren-2d）和低肾素产生株（Ren-1c）中克隆出来。每个基因长度约为9.6 kb，由9个外显子和8个内含子组成。Ren-1d基因的完整核苷酸序列已确定，并且对Ren-1c、Ren-1d和Ren-2d这三个基因的5'侧翼区域进行了比较。讨论了在DNA中发现的几种潜在调控信号的意义。