Thompson G R
MRC Lipoprotein Team, Hammersmith Hospital, London.
Gut. 1989 Nov;30 Spec No(Spec No):29-34. doi: 10.1136/gut.30.spec_no.29.
The small intestine plays a key role in lipid metabolism by absorbing fat and synthesising apoproteins. Fat malabsorption secondary to intestinal disease results in abnormalities of lipoprotein concentration and composition and can lead to deficiency of essential fatty acids and fat-soluble vitamins. Malabsorption of fat can be induced by administration of neomycin and malabsorption of bile acids by administration of anion-exchange resins or by creating a partial ileal bypass. These induced forms of malabsorption are useful in the treatment of hyperlipidaemic patients liable to atherosclerosis.
小肠通过吸收脂肪和合成载脂蛋白在脂质代谢中发挥关键作用。肠道疾病继发的脂肪吸收不良会导致脂蛋白浓度和组成异常，并可能导致必需脂肪酸和脂溶性维生素缺乏。新霉素给药可诱发脂肪吸收不良，阴离子交换树脂给药或进行部分回肠旁路手术可导致胆汁酸吸收不良。这些诱发的吸收不良形式在治疗易患动脉粥样硬化的高脂血症患者中很有用。
