新霉素对脂质吸收腔内阶段的作用。
Action of neomycin on the intraluminal phase of lipid absorption.
作者信息
Thompson G R, Barrowman J, Gutierrez L, Dowling R H
出版信息
J Clin Invest. 1971 Feb;50(2):319-23. doi: 10.1172/JCI106497.
Abstract
Administration of a single 1 g dose of neomycin sulfate to five healthy subjects simultaneously with a test meal caused a marked increase in the proportion of fatty acid and bile acid in the ultracentrifuged deposit of aspirated intestinal contents. Labeled cholesterol was precipitated in a similar manner in two hypercholesterolemic patients. Neomycin had no effect on the pancreatic lipase concentration or on the pH of intestinal contents. These results confirm that the ability of neomycin to precipitate micellar lipids is due to interaction between the polybasic neomycin molecule and ionized fatty acids and bile acids. This mechanism provides an explanation for both the steatorrhea and hypocholesterolemia induced by this compound.
摘要
对五名健康受试者在给予试餐的同时单次服用1克硫酸新霉素，导致吸出的肠内容物超速离心沉淀物中脂肪酸和胆汁酸的比例显著增加。两名高胆固醇血症患者的标记胆固醇也以类似方式沉淀。新霉素对胰脂肪酶浓度或肠内容物的pH值没有影响。这些结果证实，新霉素沉淀胶束脂质的能力是由于多碱性新霉素分子与离子化脂肪酸和胆汁酸之间的相互作用。这一机制为该化合物引起的脂肪泻和低胆固醇血症提供了解释。
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本文引用的文献
1
Neomycin inhibition of lipolysis in vitro.新霉素在体外对脂肪分解的抑制作用。
Proc Soc Exp Biol Med. 1967 Jul;125(3):905-7. doi: 10.3181/00379727-125-32236.
2
Neomycin-induced steatorrhea. A preliminary report on the in vivo hydrolysis of a long-chain unsaturated fat.新霉素诱导的脂肪泻。关于长链不饱和脂肪体内水解的初步报告。
JAMA. 1966 Jul 18;197(3):185-90. doi: 10.1001/jama.1966.03110030079030.
3
The influence of nonabsorbable antibiotics on serum lipids and the excretion of neutral sterols and bile acids.不可吸收抗生素对血脂以及中性固醇和胆汁酸排泄的影响。
Am J Clin Nutr. 1962 Aug;11:156-68. doi: 10.1093/ajcn/11.2.156.
4
An experimental malabsorption syndrome induced by neomycin.由新霉素引起的实验性吸收不良综合征。
Am J Med. 1960 Apr;28:524-33. doi: 10.1016/0002-9343(60)90146-7.
5
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JAMA. 1965 Apr 26;192:289-93. doi: 10.1001/jama.1965.03080170017004.
6
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Nature. 1964 Dec 26;204:1306. doi: 10.1038/2041306a0.
7
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