Charpak Nathalie, de la Hoz Ana María, Villegas Julieta, Gil Fabián
Fundación Canguro, Bogotá, Colombia.
Pontificia Universidad Javeriana, Bogotá, Colombia.
Acta Paediatr. 2016 May;105(5):e195-9. doi: 10.1111/apa.13377.
The aim of this study was to assess the discriminative ability of the Infant Neurological International Battery (INFANIB), applied at 3, 6 and 9 months of corrected age (CA), on neurological outcomes at 1 year of CA.
An observational analytic study was conducted on a cohort of 5857 infants, followed up to 1 year of CA in a Kangaroo Mother Care programme from 1993 to 2010 in Bogotá, Colombia. Infants were included if they had two complete INFANIB results at 3 or 6 or 9 months of CA and at 12 months of CA, including the Griffiths Scale. The outcome was defined as the presence of a neurological abnormality, as evidenced by the results of both the INFANIB and Griffiths Scale.
The sensitivity of the INFANIB at 3 months was 62.2%, and specificity was 76.1%, with a receiver operating characteristic (ROC) area of 0.69. At 6 months, the results were 77.5% for sensitivity and 74.4% for specificity (ROC 0.76), and at 9 months, they were 77.2% for sensitivity and 91.1% for specificity (ROC 0.84).
The INFANIB was an appropriate neurological screening test with regard to determining which Colombian infants would benefit from a timely intervention for neuromotor disorders.
本研究旨在评估在矫正年龄（CA）3个月、6个月和9个月时应用的国际婴儿神经学综合量表（INFANIB）对CA 1岁时神经学结局的判别能力。
对5857名婴儿进行了一项观察性分析研究，这些婴儿于1993年至2010年在哥伦比亚波哥大的袋鼠式护理项目中随访至CA 1岁。如果婴儿在CA 3个月、6个月或9个月以及CA 12个月时有两份完整的INFANIB结果，包括格里菲斯量表结果，则纳入研究。结局定义为存在神经学异常，这由INFANIB和格里菲斯量表的结果证实。
INFANIB在3个月时的敏感性为62.2%，特异性为76.1%，受试者工作特征（ROC）曲线下面积为0.69。在6个月时，敏感性结果为77.5%，特异性为74.4%（ROC 0.76），在9个月时，敏感性为77.2%，特异性为91.1%（ROC 0.84）。
就确定哪些哥伦比亚婴儿将从及时的神经运动障碍干预中受益而言，INFANIB是一项合适的神经学筛查测试。
