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[颈动脉内膜切除术。预防缺血性梗死的合理风险?]

[Carotid endarterectomy. A justifiable risk for the prevention of ischemic infarct?].

作者信息

Marx P

出版信息

Fortschr Med. 1989 Nov 30;107(34):727-32.

PMID:2691371
Abstract

Defining the position of carotid endarteriectomy (CEA) is difficult, since the average mortality and morbidity risk of this procedure--an estimated 10% or so overall in the USA--is apparently much higher than is achievable in highly specialized centers or is indicated by uncontrolled studies. No clear indication is recognizable for asymptomatic stenoses. Possible exceptions are rapidly progressing and high-grade stenoses. Prophylactic CEA within the framework of major surgical interventions increases the risk of perioperative stroke. In the event of transient ischemic attacks (TIA), carotid endarteriectomy is justifiable when cardiac sources of embolism, severe intracranial vascular stenoses and a predominantly cerebral microangiopathy have all been excluded, as also internistic and neurological disorders that increase the risks of surgery. In the acute insult stage, CEA increases mortality severalfold, and is therefore contraindicated.

摘要

确定颈动脉内膜切除术(CEA)的适用情况很困难,因为该手术的平均死亡率和发病率风险——在美国总体估计约为10%——明显高于高度专业化中心所能达到的水平,或非对照研究所示的水平。对于无症状性狭窄,没有明确的指征。可能的例外是快速进展的高度狭窄。在重大手术干预框架内进行预防性CEA会增加围手术期卒中的风险。发生短暂性脑缺血发作(TIA)时,若已排除心脏栓塞源、严重颅内血管狭窄以及主要的脑微血管病变,以及增加手术风险的内科和神经疾病,则颈动脉内膜切除术是合理的。在急性损伤阶段,CEA会使死亡率增加数倍,因此是禁忌的。

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