胰岛素注射后的胰岛血流情况。
Islet blood flow following insulin administration.
作者信息
Sparrow R A, Beckingham I J
机构信息
Department of Human Morphology, University of Nottingham Medical School, Queen's Medical Centre.
出版信息
J Anat. 1989 Apr;163:75-81.
Blood flow to the pancreatic islets of the anaesthetised rat was measured using the microsphere method. Basal flow was 29 (+/- 6) microliter/min per pancreas which was equivalent to 2.1 (+/- 0.2)% of the total pancreatic flow. The intravenous administration of 4 IU of soluble insulin, which rendered the animals hypoglycaemic, selectively increased islet flow to 93 (+/- 19) microliter/min per pancreas, equivalent to 5.4 (+/- 0.2)% of total pancreatic flow. It is suggested that this may be related to an enhanced release of glucagon from the islet A cells in response to the hypoglycaemia. Administration of 2.5 ml of a 25% glucose solution intraperitoneally gave rise to hyperglycaemia and produced a similar preferential increase in islet blood flow to 86 (+/- 25) microliter/min per pancreas, 7.4 (+/- 0.2)% of total pancreatic flow.
采用微球法测定麻醉大鼠胰岛的血流量。基础血流量为每胰腺29（±6）微升/分钟，相当于胰腺总血流量的2.1（±0.2）%。静脉注射4单位可溶性胰岛素使动物出现低血糖，可使胰岛血流量选择性增加至每胰腺93（±19）微升/分钟，相当于胰腺总血流量的5.4（±0.2）%。这可能与胰岛A细胞因低血糖而增强胰高血糖素释放有关。腹腔注射2.5毫升25%葡萄糖溶液导致血糖升高，并使胰岛血流量出现类似的优先增加，达到每胰腺86（±25）微升/分钟，占胰腺总血流量的7.4（±0.2）%。
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