Boettcher F A, Bancroft B R, Salvi R J, Henderson D
Hearing Research Laboratory, State University of New York, Buffalo 14214.
Hear Res. 1989 Nov;42(2-3):129-41. doi: 10.1016/0378-5955(89)90139-1.
The effects of sodium salicylate on auditory sensitivity, frequency selectivity, and temporal resolution were monitored in chinchillas using evoked responses recorded from the inferior colliculus. Administration of sodium salicylate (450 mg/kg/day for 5-15 days) resulted in serum salicylate levels of 25-50 mg/100 ml. The salicylate administration caused elevation of evoked response thresholds (up to 30 dB), mainly at the high frequencies. Frequency selectivity, as estimated by the Q10 dB value of evoked-response tuning curves, was poorer at 4 kHz during drug administration than during the no drug (control) condition. Temporal resolution, as estimated by recovery from forward masking was not significantly poorer during salicylate administration than before administration. However, there was a trend toward longer recovery in animals with large threshold shifts. These results are consistent with models suggesting that salicylate affects the auditory system at the level of the organ of Corti. They also suggest that while the changes in hearing that occur after salicylate administration are consistent with those seen in sensorineural hearing loss, the changes in hearing in the chinchilla are small enough to preclude the use of the drug as a practical model for sensorineural loss.
使用从下丘记录的诱发反应，监测了水杨酸钠对毛丝鼠听觉敏感性、频率选择性和时间分辨率的影响。给予水杨酸钠（450毫克/千克/天，持续5 - 15天）导致血清水杨酸盐水平达到25 - 50毫克/100毫升。水杨酸盐给药导致诱发反应阈值升高（高达30分贝），主要在高频处。通过诱发反应调谐曲线的Q10分贝值估计，给药期间4千赫处的频率选择性比无药物（对照）条件下更差。通过前向掩蔽恢复估计的时间分辨率，在水杨酸盐给药期间并不比给药前显著更差。然而，阈值大幅变化的动物有恢复时间延长的趋势。这些结果与表明水杨酸盐在柯蒂氏器水平影响听觉系统的模型一致。它们还表明，虽然水杨酸盐给药后发生的听力变化与感音神经性听力损失中所见的变化一致，但毛丝鼠的听力变化足够小，以至于不能将该药物用作感音神经性听力损失的实用模型。
