在细菌载量低的临床样本中，使用Xpert MTB/RIF v4检测法出现利福平耐药假阳性结果。
False-positive rifampin resistant results with Xpert MTB/RIF version 4 assay in clinical samples with a low bacterial load.
作者信息
Ocheretina Oksana, Byrt Erin, Mabou Marie-Marcelle, Royal-Mardi Gertrude, Merveille Yves-Mary, Rouzier Vanessa, Fitzgerald Daniel W, Pape Jean W
机构信息
Center for Global Health, Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York, New York; Les Centres GHESKIO, Port-au-Prince, Haiti.
Center for Global Health, Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York, New York.
出版信息
Diagn Microbiol Infect Dis. 2016 May;85(1):53-5. doi: 10.1016/j.diagmicrobio.2016.01.009. Epub 2016 Jan 15.
Abstract
We report investigation of 22 TB cases with positive Xpert MTB/RIF result for resistance to Rifampin and "Very Low" MTB detection level. Twelve cases were false positive without rpoB mutations, 2 were false-positives with a silent mutation in rpoB codon T508, and only 10 were true positives.
摘要
我们报告了对22例Xpert MTB/RIF检测结果呈阳性的结核病病例进行的利福平耐药性及“极低”结核分枝杆菌检测水平的调查。12例为无rpoB基因突变的假阳性，2例为rpoB密码子T508发生沉默突变的假阳性，只有10例为真阳性。
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