Navarra Riccardo, Sestieri Carlo, Conte Emanuela, Salomone Rita, Mattei Peter A, Romani Gian L, Domizio Sergio, Caulo Massimo
Department of Neuroscience and Imaging, G d'Annunzio University, Chieti, Italy Institute of Advanced Biomedical Technologies (ITAB), G d'Annunzio University, Chieti, Italy
Department of Neuroscience and Imaging, G d'Annunzio University, Chieti, Italy Institute of Advanced Biomedical Technologies (ITAB), G d'Annunzio University, Chieti, Italy.
Neuroradiol J. 2016 Apr;29(2):137-45. doi: 10.1177/1971400915628019. Epub 2016 Feb 25.
Preterm neonates represent a high-risk population for abnormal neuropsychological development. But presently, an accurate method for identifying those at risk is not available. This study evaluated the association between the microstructural organization measured with Diffusion Tensor Imaging (DTI) in term-corrected preterm neonates and subsequent motor performance. Fractional anisotropy (FA), axial diffusion (AD), mean diffusivity (MD) and radial diffusivity (RD) were determined in two regions of interest (ROIs) corresponding to the posterior limb of the internal capsule (PLIC) and cortico-spinal tract (CST). The Griffiths Mental Developmental Scales (GMDS) were longitudinally administered at 3, 6 and 15 months; and correlations between the metrics of diffusivity and the motor subscale of the GMDS were assessed using the Spearman correlation. A statistically significant negative correlation was observed between the AD of PLIC of the left hemisphere and the 3-month GMDS Locomotor Subscale. These results suggested that AD is a valid indicator of the stage of maturation of the motor pathway in preterm neonates, but not of later motor outcome.
早产儿是神经心理发育异常的高危人群。但目前，尚无准确的方法来识别这些高危儿。本研究评估了经矫正胎龄的早产儿通过弥散张量成像（DTI）测量的微观结构组织与随后运动表现之间的关联。在对应于内囊后肢（PLIC）和皮质脊髓束（CST）的两个感兴趣区域（ROI）中测定了分数各向异性（FA）、轴向扩散率（AD）、平均扩散率（MD）和径向扩散率（RD）。在3、6和15个月时纵向应用格里菲斯心理发育量表（GMDS）；并使用Spearman相关性评估扩散率指标与GMDS运动分量表之间的相关性。在左半球PLIC的AD与3个月GMDS运动分量表之间观察到具有统计学意义的负相关。这些结果表明，AD是早产儿运动通路成熟阶段的有效指标，但不是后期运动结果的有效指标。
