James W H
MRC Mammalian Development Unit, University College London.
J Laryngol Otol. 1989 Nov;103(11):1036-9. doi: 10.1017/s0022215100110904.
The sex ratio (proportion of males) of offspring of otosclerotics is significantly and substantially below expectation. To account for this and other features of the condition, it has been suggested elsewhere that otosclerosis is subject to autosomal dominant transmission with intrauterine selection against male heterozygotes. To test this hypothesis, a search was made for published data on the sexes of sibs of otosclerotics. These sibs do not have an unusual sex ratio, thus casting doubt on the hypothesis. Accordingly it is suggested here that both the condition and the sex ratios are causally related to levels of steroid hormones.
耳硬化症患者后代的性别比（男性比例）显著且大幅低于预期。为了解释这种情况及该病症的其他特征，其他地方有人提出，耳硬化症遵循常染色体显性遗传，且在子宫内存在针对男性杂合子的选择。为验证这一假说，对已发表的关于耳硬化症患者同胞性别的数据进行了检索。这些同胞的性别比并无异常，因此该假说受到质疑。据此，本文提出该病症和性别比均与类固醇激素水平存在因果关系。
