Sugihara Yutaka, Watanabe Ken-Ichi, Végvári Ákos
Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden.
Department of Biomedical Engineering, Clinical Protein Science & Imaging, BMC D13, Lund University, Lund, Sweden.
Bioanalysis. 2016 Mar;8(6):575-88. doi: 10.4155/bio-2015-0020. Epub 2016 Feb 26.
During the last decade, lateral and temporal localization of drug compounds and their metabolites have been demonstrated and dynamically developed using MS imaging. The pharmaceutical industry has recognized the potential of the technology that provides simultaneous distribution and quantitative data. In this review, we present the latest technological achievements and summarize applications of drug imaging focusing on studies about metabolites by MALDI-MS imaging. We also introduce potential areas with pharmaceutical applications that are currently under exploration, including pharmacological, toxicological characterizations and metabolic enzyme localization in comparison with drug and metabolite distribution.
在过去十年中，利用质谱成像技术已证实并动态发展了药物化合物及其代谢物的侧向和时间定位。制药行业已经认识到该技术提供同步分布和定量数据的潜力。在本综述中，我们展示了最新的技术成果，并总结了聚焦于基质辅助激光解吸电离质谱成像研究代谢物的药物成像应用。我们还介绍了目前正在探索的具有药物应用潜力的药物应用潜在领域，包括与药物和代谢物分布相比的药理学、毒理学特征以及代谢酶定位。
