Taylor K R, MacKay R J, Nelson E A, Stieler A L, Roberts J F, Castleman W L
Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
Vet Pathol. 2016 Jul;53(4):844-6. doi: 10.1177/0300985815622971. Epub 2016 Feb 25.
Two horses euthanized for neurologic deficits were diagnosed with hamartomatous myelodysplasia of the spinal cord. One was a 5-week-old Holsteiner colt exhibiting spasms of muscle rigidity in the extensor muscles of the limbs and epaxial muscles, and the other was a 3-year-old Thoroughbred colt exhibiting progressive ataxia and hypermetria in the pelvic limbs. Each had focal disorganization of the white and gray matter of the spinal cord forming a mass interspersed with neurons, glial cells, and disoriented axon bundles. In the Holsteiner colt, the mass was at the level of C5 and included islands of meningeal tissue contiguous with the leptomeninges. The mass occluded the central canal forming hydromyelia cranial to the occlusion. In the Thoroughbred colt, the mass was at the level of L1 on the dorsal periphery of the spinal cord and did not involve the central canal.
两匹因神经功能缺损而实施安乐死的马被诊断患有脊髓错构瘤性脊髓发育异常。一匹是5周大的荷斯坦纳马驹，表现出四肢伸肌和轴上肌的肌肉强直痉挛；另一匹是3岁的纯种马驹，表现出后肢进行性共济失调和辨距不良。每匹马的脊髓白质和灰质均有局灶性结构紊乱，形成一个夹杂着神经元、胶质细胞和排列紊乱的轴突束的肿块。在荷斯坦纳马驹中，肿块位于C5水平，包括与软脑膜相连的脑膜组织岛。肿块阻塞中央管，在阻塞上方形成积水性脊髓空洞症。在纯种马驹中，肿块位于脊髓背侧外周的L1水平，未累及中央管。
