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KSHV-encoded vIL-6 collaborates with deregulated c-Myc to drive plasmablastic neoplasms in mice.

作者信息

Rosean T R, Holman C J, Tompkins V S, Jing X, Krasowski M D, Rose-John S, Janz S

机构信息

Department of Pathology, University of Iowa (UI) Carver College of Medicine, Iowa City, IA, USA.

Institute of Biochemistry, Christian-Albrechts-University, Kiel, Germany.

出版信息

Blood Cancer J. 2016 Feb 26;6(2):e398. doi: 10.1038/bcj.2016.6.

DOI:10.1038/bcj.2016.6
PMID:26918362
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4771969/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5433/4771969/0d2672bc68a0/bcj20166f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5433/4771969/cdec5418bbec/bcj20166f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5433/4771969/0d2672bc68a0/bcj20166f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5433/4771969/cdec5418bbec/bcj20166f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5433/4771969/0d2672bc68a0/bcj20166f2.jpg

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Leukemia. 2015 Jan;29(1):233-7. doi: 10.1038/leu.2014.260. Epub 2014 Sep 3.
2
Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4) targets expression of cellular IRF4 and the Myc gene to facilitate lytic replication.卡波西肉瘤相关疱疹病毒的病毒干扰素调节因子4(vIRF4)靶向细胞IRF4和Myc基因的表达以促进裂解复制。
J Virol. 2014 Feb;88(4):2183-94. doi: 10.1128/JVI.02106-13. Epub 2013 Dec 11.
3
(18)F-FDG-PET/CT imaging in an IL-6- and MYC-driven mouse model of human multiple myeloma affords objective evaluation of plasma cell tumor progression and therapeutic response to the proteasome inhibitor ixazomib.
Viruses. 2022 Dec 2;14(12):2709. doi: 10.3390/v14122709.
4
Integrative genomic and transcriptomic analysis in plasmablastic lymphoma identifies disruption of key regulatory pathways.浆母细胞性淋巴瘤的综合基因组和转录组分析确定了关键调控途径的破坏。
Blood Adv. 2022 Jan 25;6(2):637-651. doi: 10.1182/bloodadvances.2021005486.
5
Metabolic Control by DNA Tumor Virus-Encoded Proteins.DNA肿瘤病毒编码蛋白的代谢调控
Pathogens. 2021 May 6;10(5):560. doi: 10.3390/pathogens10050560.
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The Role of Lytic Infection for Lymphomagenesis of Human γ-Herpesviruses.人类 γ-疱疹病毒溶原性感染在淋巴瘤发生中的作用。
Front Cell Infect Microbiol. 2021 Mar 26;11:605258. doi: 10.3389/fcimb.2021.605258. eCollection 2021.
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Mouse Models of Deregulation Driven by IgH Locus Enhancers as Models of B-Cell Lymphomagenesis.IgH 基因座增强子驱动失调的小鼠模型作为 B 细胞淋巴瘤发生的模型。
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Models of Oncoproteins Encoded by Kaposi's Sarcoma-Associated Herpesvirus.卡波西肉瘤相关疱疹病毒编码的癌蛋白模型。
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Targeting Myc in KSHV-associated primary effusion lymphoma with BET bromodomain inhibitors.用 BET 溴结构域抑制剂靶向 KSHV 相关原发性渗出性淋巴瘤中的 Myc。
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Blood. 2009 Oct 1;114(14):2952-60. doi: 10.1182/blood-2009-01-198812. Epub 2009 Aug 4.
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Plasmablastic lymphoma in an immunocompetent patient.
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