卡波西肉瘤相关疱疹病毒编码的癌蛋白模型。
Models of Oncoproteins Encoded by Kaposi's Sarcoma-Associated Herpesvirus.
机构信息
Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
出版信息
J Virol. 2019 May 15;93(11). doi: 10.1128/JVI.01053-18. Print 2019 Jun 1.
Abstract
Kaposi's sarcoma-associated herpesvirus (KSHV) is a human oncogenic virus. KSHV utilizes its proteins to modify the cellular environment to promote viral replication and persistence. Some of these proteins are oncogenic, modulating cell proliferation, apoptosis, angiogenesis, genome stability, and immune responses, among other cancer hallmarks. These changes can lead to the development of KSHV-associated malignancies. In this Gem, we focus on animal models of oncogenic KSHV proteins that were developed to enable better understanding of KSHV tumorigenesis.
摘要
卡波西肉瘤相关疱疹病毒（KSHV）是一种人类致癌病毒。KSHV 利用其蛋白质来改变细胞环境，以促进病毒复制和持续存在。其中一些蛋白质是致癌的，调节细胞增殖、凋亡、血管生成、基因组稳定性和免疫反应等癌症特征。这些变化可能导致 KSHV 相关恶性肿瘤的发展。在这篇综述中，我们重点介绍了为更好地理解 KSHV 肿瘤发生而开发的致癌 KSHV 蛋白的动物模型。
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2
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J Clin Invest. 2018 Jun 1;128(6):2519-2534. doi: 10.1172/JCI97053. Epub 2018 May 7.
3
HIV-Associated Cancers and Related Diseases.艾滋病相关癌症及相关疾病
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Oncotarget. 2017 Dec 19;9(1):1210-1228. doi: 10.18632/oncotarget.23456. eCollection 2018 Jan 2.
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