Department of Dermatology, Mayo Clinic, Scottsdale, AZ 85259, USA.
Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Cell. 2016 Feb 25;164(5):831. doi: 10.1016/j.cell.2016.02.021.
The hedgehog (Hh) signaling pathway is aberrantly activated in a majority of basal cell carcinomas (BCC). Vismodegib and sonidegib are targeted inhibitors of Smoothened (SMO). Both drugs are approved for use in locally advanced BCC (laBCC), with vismodegib also approved for metastatic BCC (mBCC).
刺猬（Hh）信号通路在大多数基底细胞癌（BCC）中异常激活。维莫德吉和索尼德吉是 Smoothened（SMO）的靶向抑制剂。这两种药物均被批准用于局部晚期 BCC（laBCC），维莫德吉也被批准用于转移性 BCC（mBCC）。
