Vakhrusheva L L, Mikaelian N P, Kniazev Iu A, Sergeeva N A
Pediatriia. 1989(11):16-8.
Diabetes mellitus children demonstrate the lowering of insulin binding by lymphocytes on appearance of the signs of insulin overdosage. After standard breakfast preceded by insulin injection such patients show a lower blood content of ATP as compared to children without metabolic signs of insulin overdosage, which may be of importance in the pathogenesis of insulin resistance development. Patients with type I diabetes mellitus and hyperlactatemia manifested the lowering of glucose assimilation by lymphocytes whatever the presence of the signs of insulin overdosage, pointing to insulin resistance.
糖尿病患儿在出现胰岛素过量体征时，淋巴细胞的胰岛素结合能力降低。在注射胰岛素后食用标准早餐，与无胰岛素过量代谢体征的儿童相比，这类患者血液中的三磷酸腺苷（ATP）含量较低，这可能在胰岛素抵抗发展的发病机制中具有重要意义。无论是否存在胰岛素过量体征，I型糖尿病和高乳酸血症患者的淋巴细胞对葡萄糖的同化作用均降低，这表明存在胰岛素抵抗。
