Kniazev Iu A, Vakhrusheva L L, Chesnokova T T, Sergeeva N A, Demidova L V
Vopr Med Khim. 1985 May-Jun;31(3):67-71.
To elucidate possible role of alterations in levels of glycosylated hemoglobin and ATP of blood in pathogenesis of diabetic impairments, 29 children with insulin-dependent diabetes mellitus were studied. In these children the blood content of the glycosylated hemoglobin was distinctly increased simultaneously with a decrease in ATP level. The alterations were especially distinct in the children the parents of which suffered from ischemic heart disease, myocardial infarction, insult, hypertension, diabetes mellitus. Development of diabetes mellitus in these children was characterized by the most severe manifestations (especially frequent and severe diabetic lesions, distinct decreases in secretion of insulin and in efficiency of the hormone). A hypothesis is discussed on possible importance of accelerated glycosylation of proteins and of a decrease in ATP synthesis for development of diabetic lesions.
为了阐明糖化血红蛋白水平和血液中ATP的变化在糖尿病性损害发病机制中的可能作用，对29名胰岛素依赖型糖尿病患儿进行了研究。在这些患儿中，糖化血红蛋白的血液含量明显增加，同时ATP水平降低。这些变化在其父母患有缺血性心脏病、心肌梗死、中风、高血压、糖尿病的患儿中尤为明显。这些患儿的糖尿病发展以最严重的表现为特征（尤其是频繁且严重的糖尿病病变、胰岛素分泌和激素效能明显降低）。讨论了关于蛋白质加速糖基化和ATP合成减少对糖尿病病变发展可能的重要性的假说。
