小鼠孕期的流感感染。
Influenza infections during pregnancy in the mouse.
作者信息
Williams K, Mackenzie J S
出版信息
J Hyg (Lond). 1977 Oct;79(2):249-57. doi: 10.1017/s0022172400053067.
Abstract
The effect of a sublethal dose (0-5 LD50) of influenza A/WSN (H0N1) administered intranasally in the 1st and 3rd weeks of pregnancy was studied in C3H inbred mice. Maternal and neonatal mortality rates were significantly increased by infections in the 3rd week of pregnancy, but not in the 1st week. Infections during the last part of the 1st week significantly depressed the growth rate of neonates. No evidence of viraemia, transplacental transmission or congenital malformations were observed from infections during either week. The results are discussed in terms of a possible model for human influenza infections during pregnancy to determine the potential risks to the mother, fetus and neonate.
摘要
在C3H近交系小鼠中研究了在妊娠第1周和第3周经鼻给予亚致死剂量（0 - 5 LD50）甲型流感病毒/WSN（H0N1）的影响。妊娠第3周感染显著增加了母体和新生儿死亡率，但第1周感染未出现这种情况。第1周后期感染显著降低了新生儿的生长速度。在这两周的感染中均未观察到病毒血症、经胎盘传播或先天性畸形的证据。根据该模型探讨了妊娠期人类流感感染的可能性，以确定对母亲、胎儿和新生儿的潜在风险。
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