Fawzy Mohamed S, Elfayoumi Abdel-Rahman, Mohamed Randa H, Fatah Ihab R Abdel, Saadawy Sara F
Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Urology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Biochem Genet. 2016 Jun;54(3):326-336. doi: 10.1007/s10528-016-9722-4. Epub 2016 Feb 26.
Cyclooxygenase-2 (COX-2), an inducible isoform of cyclooxygenase, has been reported to be correlated with tumorigenesis, tumor progression, and metastasis. We aimed to evaluate the association between COX-2 (rs2745557) polymorphism and prostate cancer (PCa), benign prostate hyperplasia (BPH) risk. We also assessed the influence of other risk factors such as obesity, smoking, diabetes in modulating the risk of PCa in Egyptian men. COX-2 (rs2745557) was genotyped in 112 PC patients, 111 BPH and 120 subjects as a control group. COX-2 and PSA levels were measured by ELISA. We found that GG genotype was associated with a 17-fold increased risk for PCa and 20-fold increased the risk for BPH more than AA genotype. Also, G allele carriers of COX-2 were associated with metastatic cancer (OR = 1.3, P < 0.05) and disease aggressiveness (OR = 3.5, P < 0.001). The coexistence of obesity, smoking, or diabetes with GG genotype may lead to increasing the risk of developing BPH (OR = 3.3, 4, and 2.7, respectively) and of developing PCa (OR = 2.9, 4.9, and 3.2, respectively). Our results showed evidence suggesting the involvement of the COX-2 (rs2745557) polymorphism and its protein in PCa or BPH initiation and progression. Also, the coexistence of COX-2 (rs2745557) and obesity, smoking, or diabetes may lead to the development of PCa or BPH.
环氧化酶-2（COX-2）是环氧化酶的一种诱导型同工酶，据报道与肿瘤发生、肿瘤进展和转移相关。我们旨在评估COX-2（rs2745557）基因多态性与前列腺癌（PCa）、良性前列腺增生（BPH）风险之间的关联。我们还评估了肥胖、吸烟、糖尿病等其他风险因素对埃及男性PCa风险的调节作用。对112例PC患者、111例BPH患者和120名受试者作为对照组进行了COX-2（rs2745557）基因分型。通过酶联免疫吸附测定法测量COX-2和前列腺特异性抗原（PSA）水平。我们发现，与AA基因型相比，GG基因型使PCa风险增加17倍，使BPH风险增加20倍。此外，COX-2的G等位基因携带者与转移性癌症（优势比[OR]=1.3，P<0.05）和疾病侵袭性（OR=3.5，P<0.001）相关。肥胖、吸烟或糖尿病与GG基因型共存可能会导致患BPH（OR分别为3.3、4和2.7）和患PCa（OR分别为2.9、4.9和3.2）的风险增加。我们的结果表明，有证据表明COX-2（rs2745557）基因多态性及其蛋白参与了PCa或BPH的发生和进展。此外，COX-2（rs2745557）与肥胖、吸烟或糖尿病共存可能会导致PCa或BPH的发生。
