Department of Urology, Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin, China.
BMC Immunol. 2012 Mar 21;13:14. doi: 10.1186/1471-2172-13-14.
Evidence is accumulating that chronic inflammation may have an important role in prostate cancer (PCa). The COX-2 polymorphism rs2745557 (+202 C/T) has been extensively investigated as a potential risk factor for PCa, but the results have thus far been inconclusive. This meta-analysis was performed to derive a more precise estimation of the association.
A comprehensive search was conducted to identify all case-control studies of COX-2 rs2745557 polymorphism and PCa risk. We used odds ratios (ORs) to assess the strength of the association, and 95% confidence intervals (CIs) give a sense of the precision of the estimate. Statistical analyses were performed by Review Manage, version 5.0 and Stata 10.0.
A total of 8 available studies were considered in the present meta-analysis, with 11356 patients and 11641 controls for rs2745557. When all groups were pooled, there was no evidence that rs2745557 had significant association with PCa under co-dominant, recessive, over-dominant, and allelic models. However, our analysis suggested that rs2745557 was associated with a lower PCa risk under dominant model in overall population (OR=0.85, 95%CI=0.74-0.97, P=0.02). When stratifying for race, there was a significant association between rs2745557 polymorphism and lower PCa risk in dominant model comparison in the subgroup of Caucasians (OR=0.86, 95%CI=0.75-0.99, P=0.04), but not in co-dominant, recessive, over-dominant and allelic comparisons.
Based on our meta-analysis, COX-2 rs2745557 was associated with a lower PCa risk under dominant model in Caucasians.
越来越多的证据表明，慢性炎症可能在前列腺癌（PCa）中起重要作用。COX-2 多态性 rs2745557（+202C/T）已被广泛研究为 PCa 的潜在危险因素，但迄今为止结果尚无定论。进行这项荟萃分析是为了更准确地评估这种关联。
进行了全面的搜索，以确定所有关于 COX-2 rs2745557 多态性与 PCa 风险的病例对照研究。我们使用比值比（OR）来评估关联的强度，95%置信区间（CI）给出了估计的精度。统计分析使用 Review Manage 版本 5.0 和 Stata 10.0 进行。
本荟萃分析共纳入 8 项研究，共纳入 11356 例患者和 11641 例对照，用于 rs2745557。当所有组合并时，没有证据表明 rs2745557 与 PCa 具有显著的共显性、隐性、超显性和等位基因模型关联。然而，我们的分析表明，rs2745557 与总体人群中的显性模型下较低的 PCa 风险相关（OR=0.85，95%CI=0.74-0.97，P=0.02）。按种族分层时，rs2745557 多态性与显性模型比较在白人群体中与较低的 PCa 风险相关（OR=0.86，95%CI=0.75-0.99，P=0.04），但在共显性、隐性、超显性和等位基因比较中无显著关联。
根据我们的荟萃分析，COX-2 rs2745557 与白种人显性模型下较低的 PCa 风险相关。
