Podszus T
Pneumologie. 1989 Nov;43 Suppl 1:639-42.
Sleep-related breathing disorders often lead to cardio-pulmonary and cardiovascular complications as well as to cardiac failure. It is thus necessary to carry out a detailed medical diagnostic work-up to assess the cardiac risk before initiating therapy. Basic requirements for successful therapy are preventive measures. Weight reduction for the usually overweight patients, avoidance of alcohol, sedatives and tranquilizers, and adequate sleep hygiene. Before a vacation at high altitudes, individual advice is needed. Medical treatment includes the prescription of respiration stimulants in certain cases as also--after careful estimation of the risks--prescription of tricyclic antidepressants. Today, the application of calcium-channel blockers and theophylline seems to be most successful. In an examination of our own involving 20 patients we found a significant reduction in the apnoea index due to treatment with euphyllong. In cases of pronounced findings and corresponding symptoms the use of mechanical measures, especially of nasal CPAP therapy can be recommended in more than 80% of patients. Those who cannot be adequately treated by the methods mentioned above, must be provided with a tracheostomy. This drastic form of therapy should only be considered after a thorough diagnostic evaluation and exhaustive use of all other methods. At present, oxygen therapy is still under discussion in the literature and can be recommended only in cases of an "overlap" syndrome.
睡眠相关呼吸障碍常导致心肺和心血管并发症以及心力衰竭。因此,在开始治疗前有必要进行详细的医学诊断检查以评估心脏风险。成功治疗的基本要求是采取预防措施。对于通常超重的患者,要减轻体重,避免饮酒、使用镇静剂和安眠药,并保持良好的睡眠卫生习惯。在前往高海拔地区度假前,需要个性化建议。药物治疗包括在某些情况下开具呼吸兴奋剂处方,以及在仔细评估风险后开具三环类抗抑郁药处方。如今,应用钙通道阻滞剂和茶碱似乎最为成功。在我们自己对20名患者的一项检查中,我们发现使用优菲林治疗后呼吸暂停指数显著降低。对于症状明显的患者,在超过80%的患者中可推荐使用机械措施,尤其是鼻持续气道正压通气(CPAP)治疗。那些无法通过上述方法得到充分治疗的患者,必须进行气管造口术。这种激进的治疗方式仅应在经过全面诊断评估并充分尝试所有其他方法后才予以考虑。目前,文献中对氧疗仍存在争议,仅在“重叠”综合征的情况下才可推荐使用。