Jeong In Hye, Choi Joon Yul, Kim Su-Hyun, Hyun Jae-Won, Joung AeRan, Lee Jongho, Kim Ho Jin
Department of Neurology, Research Institute and Hospital, National Cancer Center, Goyang-si, Republic of Korea.
Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea.
Mult Scler. 2016 Oct;22(12):1616-1620. doi: 10.1177/1352458516636247. Epub 2016 Feb 26.
Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are inflammatory autoimmune diseases of the central nervous system. We hypothesized that the degree of demyelination within lesions in MS and NMOSD would differ as the pathophysiology of the two diseases do. We used myelin water imaging to compare the myelin water fraction (MWF) in 106 periventricular white matter (PVWM) lesions in 27 MS patients and 51 PVWM lesions in 20 NMOSD patients. The MWF was significantly reduced in the MS compared with the NMOSD lesions, suggesting that myelin loss was more severe in MS than in NMOSD.
多发性硬化症（MS）和视神经脊髓炎谱系障碍（NMOSD）是中枢神经系统的炎性自身免疫性疾病。我们推测，由于这两种疾病的病理生理学不同，MS和NMOSD病灶内的脱髓鞘程度也会有所不同。我们使用髓磷脂水成像技术比较了27例MS患者的106个脑室周围白质（PVWM）病灶和20例NMOSD患者的51个PVWM病灶中的髓磷脂水分数（MWF）。与NMOSD病灶相比，MS病灶中的MWF显著降低，这表明MS中的髓磷脂损失比NMOSD更严重。
