Ladoux Benoit, Mège René-Marc, Trepat Xavier
Institut Jacques Monod (IJM), CNRS UMR 7592 et Université Paris Diderot, Paris, France; Mechanobiology Institute, National University of Singapore, 5A Engineering Drive 1, 117411, Singapore.
Institut Jacques Monod (IJM), CNRS UMR 7592 et Université Paris Diderot, Paris, France.
Trends Cell Biol. 2016 Jun;26(6):420-433. doi: 10.1016/j.tcb.2016.02.002. Epub 2016 Feb 23.
Directed cell migration is a complex process that involves front-rear polarization, characterized by cell adhesion and cytoskeleton-based protrusion, retraction, and contraction of either a single cell or a cell collective. Single cell polarization depends on a variety of mechanochemical signals including external adhesive cues, substrate stiffness, and confinement. In cell ensembles, coordinated polarization of migrating tissues results not only from the application of traction forces on the extracellular matrix but also from the transmission of mechanical stress through intercellular junctions. We focus here on the impact of mechanical cues on the establishment and maintenance of front-rear polarization from single cell to collective cell behaviors through local or large-scale mechanisms.
定向细胞迁移是一个复杂的过程，涉及前后极化，其特征是单细胞或细胞群体基于细胞粘附和细胞骨架的突出、回缩和收缩。单细胞极化取决于多种机械化学信号，包括外部粘附线索、底物硬度和限制。在细胞集合体中，迁移组织的协调极化不仅源于对细胞外基质施加牵引力，还源于通过细胞间连接传递机械应力。我们在此关注机械线索通过局部或大规模机制对从单细胞到集体细胞行为的前后极化的建立和维持的影响。
