Cell Polarity, Migration and Cancer Unit, Institut Pasteur, UMR3691 CNRS, Équipe Labellisée Ligue Contre le Cancer, F-75015, Paris, France; Sorbonne Université, Collège Doctoral, F-75005 Paris, France.
Cell Polarity, Migration and Cancer Unit, Institut Pasteur, UMR3691 CNRS, Équipe Labellisée Ligue Contre le Cancer, F-75015, Paris, France; School of Life Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
Curr Opin Cell Biol. 2020 Feb;62:114-122. doi: 10.1016/j.ceb.2019.10.001. Epub 2019 Nov 19.
Collective cell migration does not only reflect the migration of cells at a similar speed and in the same direction, it also implies the emergence of new properties observed at the level of the cell group. This collective behavior relies on interactions between the cells and the establishment of a hierarchy amongst cells with leaders driving the group of followers. Here, we make the parallel between the front-to-rear polarity axis in single cell and the front-to-rear multicellular-scale polarity of a migrating collective which established through exchange of biochemical and mechanical information from the front to the rear and vice versa. Such multicellular-scale polarity gives the migrating group the possibility to better sense and adapt to energy, biochemical and mechanical constraints and facilitates migration over long distances in complex and changing environments.
群体细胞迁移不仅反映了细胞以相似的速度和相同的方向迁移，还暗示了在细胞群体水平上观察到的新特性的出现。这种群体行为依赖于细胞之间的相互作用，并在细胞之间建立一个层次结构，领导者驱动跟随者群体。在这里，我们将单细胞中的前后极性轴与迁移的群体的前后多细胞尺度极性进行了平行比较，这种极性是通过从前到后和从后到前的生化和机械信息的交换建立的。这种多细胞尺度的极性使迁移的群体能够更好地感知和适应能量、生化和机械限制，并促进在复杂和不断变化的环境中长距离迁移。
