自噬中ULK1复合物的结构与功能
Structure and function of the ULK1 complex in autophagy.
作者信息
Lin Mary G, Hurley James H
机构信息
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, United States; California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720, United States.
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, United States; California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720, United States; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, United States.
出版信息
Curr Opin Cell Biol. 2016 Apr;39:61-8. doi: 10.1016/j.ceb.2016.02.010. Epub 2016 Feb 27.
The ULK1 complex initiates autophagosome formation, linking cellular nutrient status to downstream events in autophagy. Recent work suggests that the ULK1 complex might also be activated in selective autophagy independent of nutrient or energy status. In this review we will discuss our current understanding of how the ULK1 complex is regulated by different signals, as well as how this complex then regulates other components of the autophagy machinery. Recently obtained structural data both on ULK1 and the orthologous yeast Atg1 complex are beginning to shed light on the higher-order organization of ULK1 complex. Ultimately, these insights might make it possible to understand how cargo organization and structure recruits and regulates ULK1 in selective autophagy initiation.
ULK1复合物启动自噬体形成，将细胞营养状态与自噬下游事件联系起来。最近的研究表明，ULK1复合物也可能在选择性自噬中被激活，而与营养或能量状态无关。在这篇综述中，我们将讨论目前对ULK1复合物如何受不同信号调节的理解，以及该复合物随后如何调节自噬机制的其他组分。最近获得的关于ULK1和直系同源酵母Atg1复合物的结构数据，开始为ULK1复合物的高阶组织提供线索。最终，这些见解可能有助于理解货物的组织和结构如何在选择性自噬起始过程中招募和调节ULK1。
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