Li Aizhuo, Wang Jiannan, Qu Yi
Department of Ultrasound, The First Affiliated Hospital of China Medical University, Shenyang, China.
Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, China.
Front Cell Dev Biol. 2025 Jul 15;13:1637451. doi: 10.3389/fcell.2025.1637451. eCollection 2025.
Ubiquitination serves as a dynamic post-translational modification that enables rapid and precise regulation of cellular signaling networks. TRIM21, as an important member of the TRIM family, is a protein with E3 ubiquitin ligase activity. By specifically recognizing and ubiquitinating various substrate proteins, it plays a pivotal regulatory role in tumorigenesis and development. Moreover, TRIM21 has been found to play a multi-faceted role in cellular autophagy, metabolic reprogramming, immune escape, tumor proliferation, metastasis and resistance to cell death by regulating the stability and function of key proteins. In this review, we provided an in-depth understanding of the specific mechanism of TRIM21 in different biological processes and tumor types, which contributes to the development of novel targeted therapeutic strategies targeting TRIM21.
泛素化作为一种动态的翻译后修饰，能够对细胞信号网络进行快速而精确的调控。TRIM21作为TRIM家族的重要成员，是一种具有E3泛素连接酶活性的蛋白质。通过特异性识别并泛素化各种底物蛋白，它在肿瘤发生和发展过程中发挥着关键的调控作用。此外，人们发现TRIM21通过调节关键蛋白的稳定性和功能，在细胞自噬、代谢重编程、免疫逃逸、肿瘤增殖、转移及细胞死亡抗性等方面发挥多方面作用。在本综述中，我们深入了解了TRIM21在不同生物学过程和肿瘤类型中的具体机制，这有助于开发针对TRIM21的新型靶向治疗策略。
