Rivas-Larrauri Francisco, Yamazaki-Nakashimada Marco Antonio
Servicio de Inmunología Clínica, Instituto Nacional de Pediatría Insurgentes Sur, México D.F., México.
Servicio de Inmunología Clínica, Instituto Nacional de Pediatría Insurgentes Sur, México D.F., México.
Reumatol Clin. 2016 Sep-Oct;12(5):274-81. doi: 10.1016/j.reuma.2016.01.005. Epub 2016 Feb 26.
Systemic lupus erythematosus (SLE) is a multisystemic disease with a variety of clinical presentations. Monogenic predisposing conditions to the development of this disease have been described. As examples, an impaired expression of interferon-α regulated genes or complement deficiencies have been reported in patients with SLE, with particular clinical presentations. Those defects present particular presentations and a different severity, making an argument that lupus is not a single disease but many. Treatment could be individualized depending on the underlying defect generating the subtype of the disease.
系统性红斑狼疮（SLE）是一种具有多种临床表现的多系统疾病。已经描述了导致这种疾病发生的单基因易感情况。例如，在患有SLE的患者中，已报告干扰素-α调节基因表达受损或补体缺陷，并伴有特定的临床表现。这些缺陷呈现出特定的表现和不同的严重程度，这表明狼疮不是单一疾病，而是多种疾病。治疗可以根据导致疾病亚型的潜在缺陷进行个体化。
