Hastie N D, Allshire R C
Trends Genet. 1989 Oct;5(10):326-31. doi: 10.1016/0168-9525(89)90137-6.
The ends of human chromosomes have been shown recently to resemble those of simple organisms. With this in mind, we discuss the nature and possible significance of rare chromosome fusion events thought to involve telomeres, particularly those fusion events found in some tumours. Also we argue that interstitial telomere-like stretches may be particularly prone to recombination, breakage and fragility.
最近研究表明，人类染色体的末端与简单生物体的染色体末端相似。基于此，我们讨论了被认为涉及端粒的罕见染色体融合事件的性质及其可能的意义，尤其是在某些肿瘤中发现的那些融合事件。此外，我们认为，染色体中间类似端粒的片段可能特别容易发生重组、断裂和脆性。
