室内灰尘中细胞外囊泡的IgG致敏与非嗜酸性粒细胞性哮喘、慢性阻塞性肺疾病和肺癌的患病率密切相关。
IgG Sensitization to Extracellular Vesicles in Indoor Dust Is Closely Associated With the Prevalence of Non-Eosinophilic Asthma, COPD, and Lung Cancer.
作者信息
Kim You Sun, Choi Jun Pyo, Kim Min Hye, Park Han Ki, Yang Sejung, Kim Youn Seup, Kim Tae Bum, Cho You Sook, Oh Yeon Mok, Jee Young Koo, Lee Sang Do, Kim Yoon Keun
机构信息
Asan Institute for Life Science and University of Ulsan College of Medicine, Seoul, Korea.
Institute of Convergence Medicine, Ewha Womans University Medical Center and Ewha Womans University School of Medicine, Seoul, Korea.
出版信息
Allergy Asthma Immunol Res. 2016 May;8(3):198-205. doi: 10.4168/aair.2016.8.3.198.
PURPOSE
Recent experimental evidence shows that extracellular vesicles (EVs) in indoor dust induce neurtrophilic pulmonary inflammation, which is a characteristic pathology in patients with severe asthma and chronic obstructive pulmonary disease (COPD). In addition, COPD is known to be an important risk factor for lung cancer, irrespective of cigarette smoking. Here, we evaluated whether sensitization to indoor dust EVs is a risk for the development of asthma, COPD, or lung cancer.
METHODS
Serum IgG antibodies against dust EVs were measured in 90 healthy control subjects, 294 asthmatics, 242 COPD patients, and 325 lung cancer patients. Serum anti-dust EV IgG titers were considered high if they exceeded a 95 percentile value of the control subjects. Age-, gender-, and cigarette smoke-adjusted multiple logistic regression analyses were performed to determine odds ratios (ORs) for asthma, COPD, and lung cancer patients vs the control subjects.
RESULTS
In total, 4.4%, 13.6%, 29.3%, and 54.9% of the control, asthma, COPD, and lung cancer groups, respectively, had high serum anti-dust EV IgG titers. Adjusted multiple logistic regression revealed that sensitization to dust EVs (high serum anti-dust EV IgG titer) was an independent risk factor for asthma (adjusted OR, 3.3; 95% confidence interval [CI], 1.1-10.0), COPD (adjusted OR, 8.0; 95% CI, 2.0-32.5) and lung cancer (adjusted OR, 38.7; 95% CI, 10.4-144.3).
CONCLUSIONS
IgG sensitization to indoor dust EVs appears to be a major risk for the development of asthma, COPD, and lung cancer.
目的
最近的实验证据表明，室内灰尘中的细胞外囊泡（EVs）可诱发嗜中性粒细胞性肺部炎症，这是重度哮喘和慢性阻塞性肺疾病（COPD）患者的特征性病理表现。此外，已知COPD是肺癌的重要危险因素，与吸烟无关。在此，我们评估了对室内灰尘EVs致敏是否是哮喘、COPD或肺癌发生的危险因素。
方法
检测了90名健康对照者、294名哮喘患者、242名COPD患者和325名肺癌患者血清中针对灰尘EVs的IgG抗体。如果血清抗灰尘EV IgG滴度超过对照者的第95百分位数，则认为其较高。进行年龄、性别和吸烟调整后的多因素logistic回归分析，以确定哮喘、COPD和肺癌患者与对照者相比的比值比（OR）。
结果
总体而言，对照、哮喘、COPD和肺癌组中分别有4.4%、13.6%、29.3%和54.9%的患者血清抗灰尘EV IgG滴度较高。调整后的多因素logistic回归显示，对灰尘EVs致敏（血清抗灰尘EV IgG滴度较高）是哮喘（调整后OR，3.3；95%置信区间[CI]，1.1 - 10.0）、COPD（调整后OR，8.0；95% CI，2.0 - 32.5）和肺癌（调整后OR，38.7；95% CI，10.4 - 144.3）的独立危险因素。
结论
对室内灰尘EVs的IgG致敏似乎是哮喘、COPD和肺癌发生的主要危险因素。
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