Department of Genetics, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Oncogene. 2016 Oct 6;35(40):5215-5223. doi: 10.1038/onc.2016.30. Epub 2016 Feb 29.
Mixed lineage leukemia caused by MLL fusion proteins is still a mostly incurable disease. Research on novel treatment strategies has gained momentum in the last years with the elucidation of the molecular mechanisms underlying the transforming potential of these powerful oncoproteins. This review summarizes the recent developments in this area including new attempts to treat MLL in a rational way by exploiting the biochemical vulnerabilities of the leukemogenic process.
由 MLL 融合蛋白引起的混合谱系白血病仍然是一种基本无法治愈的疾病。随着这些强大致癌蛋白的转化潜能的分子机制的阐明，对新型治疗策略的研究在过去几年中得到了迅速发展。本综述总结了这一领域的最新进展，包括通过利用白血病发生过程中的生化脆弱性，以合理的方式治疗 MLL 的新尝试。
