Jamasbi Elaheh, Wade John D, Separovic Frances, Hossain Mohammed A
School of Chemistry, Bio21 Institute, University of Melbourne, VIC 3010; and The Florey Institute of Neuroscience and Mental Health, University of Melbourne, VIC 3010, Australia.
Curr Med Chem. 2016;23(9):884-92. doi: 10.2174/0929867323666160229113911.
Amyloid beta peptide (Aβ) is recognised as a main feature of Alzheimer's disease (AD). Increasing evidence suggests that small soluble oligomers of Aβ are the toxic form of the peptide and may instigate AD. Different factors including some key residues within Aβ molecule, the cell membrane, prion protein and metals play important roles in developing AD. Significant progress has been made to understand these factors and elucidate the mechanism of cytotoxicity of Aβ. This review summarizes recent findings in the area of Aβ and AD research, and this current knowledge could enable medicinal chemists to design and develop therapeutics to treat AD.
β淀粉样肽（Aβ）被认为是阿尔茨海默病（AD）的主要特征。越来越多的证据表明，Aβ的小可溶性寡聚体是该肽的毒性形式，可能引发AD。包括Aβ分子内的一些关键残基、细胞膜、朊病毒蛋白和金属在内的不同因素在AD的发展中起重要作用。在理解这些因素和阐明Aβ细胞毒性机制方面已经取得了重大进展。本综述总结了Aβ与AD研究领域的最新发现，这些现有知识可使药物化学家设计和开发治疗AD的药物。
