Wang Yong, Ma Heng, Hao Xiaochen, Yang Jun, Chen Qiujing, Lu Lin, Zhang Ruiyan
Department of Cardiology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Institute of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Sci Rep. 2016 Feb 29;6:22283. doi: 10.1038/srep22283.
Whether serum calcium is associated with heart systolic function in patients with established coronary artery disease (CAD) and acute myocardial infarction (AMI) remains to be elucidated. This study is aimed to assess the association between serum calcium and left ventricular systolic dysfunction in a Chinese population of CAD. The cross-sectional study included 5938 CAD patients with and without AMI in China. The factors associated with AMI and left ventricular ejection fraction (LVEF) were evaluated. The data showed that AMI patients had lower serum calcium levels (2.11 ± 0.13 vs 2.20 ± 0.10 mmol/l, P < 0.001) than those without AMI. Multiple logistic regression analysis exhibited that serum calcium (OR: 0.000, 95% CI: 0.000-0.001) was one of the independent factors correlated with AMI. CAD patients with and without AMI when LVEF <50% had lower serum calcium levels than those when LVEF ≥50% respectively. Serum calcium was independently associated with LVEF and LVEF <50% in CAD patients with and without AMI respectively using multivariate analysis. The independent association between serum calcium and LVEF still existed among CAD patients when LVEF ≥50%. Serum calcium levels are significantly decreased following AMI. Low serum calcium is independently correlated with left ventricular systolic dysfunction in CAD patients with and without AMI.
在已确诊冠心病（CAD）和急性心肌梗死（AMI）的患者中，血清钙是否与心脏收缩功能相关仍有待阐明。本研究旨在评估中国CAD人群中血清钙与左心室收缩功能障碍之间的关联。这项横断面研究纳入了中国5938例有或无AMI的CAD患者。评估了与AMI和左心室射血分数（LVEF）相关的因素。数据显示，AMI患者的血清钙水平（2.11±0.13 vs 2.20±0.10 mmol/l，P<0.001）低于无AMI的患者。多因素logistic回归分析显示，血清钙（OR：0.000，95%CI：0.000 - 0.001）是与AMI相关的独立因素之一。LVEF<50%的有或无AMI的CAD患者的血清钙水平分别低于LVEF≥50%的患者。使用多因素分析，血清钙分别与有或无AMI的CAD患者的LVEF以及LVEF<50%独立相关。在LVEF≥50%的CAD患者中，血清钙与LVEF之间的独立关联仍然存在。AMI后血清钙水平显著降低。低血清钙与有或无AMI的CAD患者的左心室收缩功能障碍独立相关。
