Department of Organic Chemistry and ‡Department of Chemical Research Support, Weizmann Institute of Science , Rehovot 76100, Israel.
J Am Chem Soc. 2016 Apr 6;138(13):4298-301. doi: 10.1021/jacs.5b13519. Epub 2016 Mar 25.
The catalytic dehydrogenative coupling of alcohols and amines to form aldimines represents an environmentally benign methodology in organic chemistry. This has been accomplished in recent years mainly with precious-metal-based catalysts. We present the dehydrogenative coupling of alcohols and amines to form imines and H2 that is catalyzed, for the first time, by a complex of the earth-abundant Mn. Detailed mechanistic study was carried out with the aid of NMR spectroscopy, intermediate isolation, and X-ray analysis.
醇和胺的催化脱氢偶联形成亚胺是有机化学中一种环境友好的方法。近年来，主要使用贵金属基催化剂来实现这一转化。我们首次报道了由丰富的锰配合物催化醇和胺脱氢偶联形成亚胺和氢气。借助 NMR 光谱、中间体分离和 X 射线分析进行了详细的机理研究。
