Seçil Yaprak, Arıcı Şehnaz, İncesu Tülay Kurt, Gürgör Nevin, Beckmann Yeşim, Ertekin Cumhur
Neurology Department, Katip Çelebi University Atatürk Training and Research Hospital, Basın Sitesi, 35360 Izmir, Turkey.
Neurology Department, Katip Çelebi University Atatürk Training and Research Hospital, Basın Sitesi, 35360 Izmir, Turkey.
Neurophysiol Clin. 2016 Jun;46(3):171-8. doi: 10.1016/j.neucli.2015.12.007. Epub 2016 May 11.
To investigate electrophysiological parameters of swallowing in all stages of Alzheimer's disease.
Forty Alzheimer's disease patients, 20 age-matched normal controls and 20 young normal controls were included. Dysphagia limit (DL) and sequential water swallowing (SWS) tests were performed. Cardiac rhythm, respiration and sympathetic skin responses were concomitantly recorded.
Dysphagia was found in 30/40 (75%) of Alzheimer's disease patients. Mean volume at the DL test was significantly reduced (16.5±1.0mL) in the Alzheimer's disease group. Swallowing and apnea times in the SWS test were significantly prolonged in elderly controls, but even longer in Alzheimer's disease patients.
Alzheimer's disease patients had electrophysiological features of dysphagia, even in the early period of disease. The cortical involvement and severity of cognitive disorder can increase swallowing problems, but subclinical signs of dysphagia may be observed even in patients with mild or moderate Alzheimer's disease.
研究阿尔茨海默病各阶段吞咽的电生理参数。
纳入40例阿尔茨海默病患者、20例年龄匹配的正常对照者和20例年轻正常对照者。进行吞咽困难极限（DL）和连续水吞咽（SWS）测试。同时记录心律、呼吸和交感皮肤反应。
40例阿尔茨海默病患者中有30例（75%）存在吞咽困难。阿尔茨海默病组DL测试的平均容量显著降低（16.5±1.0mL）。老年对照组SWS测试中的吞咽和呼吸暂停时间显著延长，但阿尔茨海默病患者更长。
阿尔茨海默病患者即使在疾病早期也具有吞咽困难的电生理特征。皮质受累和认知障碍的严重程度会增加吞咽问题，但即使在轻度或中度阿尔茨海默病患者中也可能观察到吞咽困难的亚临床体征。
