[Drug-induced bone pathology].

Some drugs are potentially toxic, directly or indirectly, to bone tissue. However, the banality of the bone pathology renders a definitive association difficult. Osteomalacia can be triggered by anticonvulsants, aluminum, fluoride or diphosphonates. Osteoporosis is induced more commonly with corticosteroids, long-term heparin administration or hypothyroid hormonal replacement therapy. The link between the bone disease and the suspected drug is accepted only if there is no other risk factor and after histomorphometric confirmation of the bone pathology.