Schiano A, Chouc P Y, Desnuelle C, Serratrice G
Service de Neurologie et des Maladies de l'Appareil Locometeur, CHU de la Timone, Marseille.
Ann Med Interne (Paris). 1989;140(7):605-8.
Some drugs are potentially toxic, directly or indirectly, to bone tissue. However, the banality of the bone pathology renders a definitive association difficult. Osteomalacia can be triggered by anticonvulsants, aluminum, fluoride or diphosphonates. Osteoporosis is induced more commonly with corticosteroids, long-term heparin administration or hypothyroid hormonal replacement therapy. The link between the bone disease and the suspected drug is accepted only if there is no other risk factor and after histomorphometric confirmation of the bone pathology.
某些药物对骨组织具有直接或间接的潜在毒性。然而，骨病理学的常见性使得明确的关联难以确定。抗惊厥药、铝、氟化物或双膦酸盐可引发骨软化症。骨质疏松症更常见于使用皮质类固醇、长期肝素治疗或甲状腺功能减退激素替代治疗的情况下。只有在不存在其他风险因素且经组织形态计量学确认骨病理学后，骨疾病与可疑药物之间的关联才会被认可。
