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痤疮丙酸杆菌接种于兔椎间盘内引起的Modic改变和椎间盘退变：一项初步研究。

Modic Changes and Disc Degeneration Caused by Inoculation of Propionibacterium acnes inside Intervertebral Discs of Rabbits: A Pilot Study.

作者信息

Chen Zhe, Zheng Yuehuan, Yuan Ye, Jiao Yucheng, Xiao Jiaqi, Zhou Zezhu, Cao Peng

机构信息

Department of Orthopedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese-Western Medicine, Shanghai Institute of Traumatology and Orthopedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Department of Orthopedics, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai 201821, China.

出版信息

Biomed Res Int. 2016;2016:9612437. doi: 10.1155/2016/9612437. Epub 2016 Jan 26.

DOI:10.1155/2016/9612437
PMID:26925420
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4746301/
Abstract

PURPOSE

To investigate whether P. acnes could induce disc degeneration and Modic changes when inoculated into the discs of rabbits.

METHOD

A wild-type strain of P. acnes isolated from a patient associated with Modic change and disc degeneration was inoculated into the intervertebral discs of rabbits. Meanwhile, S. aureus was injected into the discs to establish a model of discitis as the comparison and a standard strain of P. acnes was inoculated as the control. MRI and histological change were observed.

RESULTS

Both the P. acnes-inoculated and S. aureus-inoculated rabbits showed hyperintense signals at endplates and hypointense signals at nucleus pulposus on T2WI. However, P. acnes only resulted in moderate disc degeneration and endplates rupture in histological examination, which was different from the pathological change of discitis caused by S. aureus. In addition, higher death rates (2/3 versus 0/5) were observed in S. aureus-inoculated rabbits.

CONCLUSION

Compared to S. aureus, the pathological change caused by P. acnes would be considered as Modic-I change and disc degeneration rather than a discitis.

摘要

目的

研究痤疮丙酸杆菌接种到兔椎间盘后是否能诱导椎间盘退变和Modic改变。

方法

将从一名与Modic改变和椎间盘退变相关的患者分离出的痤疮丙酸杆菌野生型菌株接种到兔的椎间盘内。同时，将金黄色葡萄球菌注入椎间盘以建立椎间盘炎模型作为对照，并接种痤疮丙酸杆菌标准菌株作为控制。观察磁共振成像（MRI）和组织学变化。

结果

接种痤疮丙酸杆菌和接种金黄色葡萄球菌的兔在T2加权成像（T2WI）上均显示终板高信号和髓核低信号。然而，在组织学检查中，痤疮丙酸杆菌仅导致中度椎间盘退变和终板破裂，这与金黄色葡萄球菌引起的椎间盘炎的病理变化不同。此外，接种金黄色葡萄球菌 的兔的死亡率更高（2/3对0/5）。

结论

与金黄色葡萄球菌相比，痤疮丙酸杆菌引起的病理变化将被视为Modic-I改变和椎间盘退变而非椎间盘炎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fdc/4746301/c4aeef6fd420/BMRI2016-9612437.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fdc/4746301/33caeae64aac/BMRI2016-9612437.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fdc/4746301/fef4a003ce6d/BMRI2016-9612437.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fdc/4746301/c4aeef6fd420/BMRI2016-9612437.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fdc/4746301/33caeae64aac/BMRI2016-9612437.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fdc/4746301/fef4a003ce6d/BMRI2016-9612437.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fdc/4746301/c4aeef6fd420/BMRI2016-9612437.003.jpg

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