内皮素引起神经胶质细胞内游离钙升高及有丝分裂。
Free calcium rise and mitogenesis in glial cells caused by endothelin.
作者信息
Supattapone S, Simpson A W, Ashley C C
机构信息
University Laboratory of Physiology, Oxford, U.K.
出版信息
Biochem Biophys Res Commun. 1989 Dec 29;165(3):1115-22. doi: 10.1016/0006-291x(89)92718-6.
PMID:2692560
Abstract
The peptide endothelin causes a biphasic rise in intracellular free calcium levels in cultured Type-1 astrocytes and C6 glioma cells, suggesting that glial cells may be the physiological target of endothelin in the brain. Endothelin also causes a calcium-dependent increase [3H]thymidine incorporation in primary cultures of rat cerebellum, indicating that, among other possible roles, this peptide may mediate mitogenesis in brain.
摘要
肽内皮素可使培养的1型星形胶质细胞和C6胶质瘤细胞内的游离钙水平出现双相升高，这表明神经胶质细胞可能是大脑中内皮素的生理靶点。内皮素还可使大鼠小脑原代培养物中的[3H]胸腺嘧啶核苷掺入量出现钙依赖性增加，这表明除其他可能作用外，该肽可能介导大脑中的有丝分裂。
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