Schlenter W W, Blessing R, Heintz B
Klinik für Hals-Nasen-Ohrenheilkunde, Medizinische Universität zu Lübeck.
Laryngorhinootologie. 1989 Dec;68(12):671-4. doi: 10.1055/s-2007-998427.
In a multicenter randomized double-blind study, 284 patients with chronic purulent sinusitis were treated with an oral immunostimulant or placebo in addition to standard therapy (antibiotics, mucolytics, inhalants). Treatment lasted for three ten-day periods in three consecutive months. At the start and during the therapy as well as after six months, symptoms were assessed on the basis of a scoring system and the X-rays of the nasal sinuses evaluated. During the course of therapy and the follow-up period, improvement of the major symptoms headache, purulent nasal discharge, cough, and expectoration was statistically significant in the immunostimulant group as compared with the placebo group, objective evidence being provided by the X-ray examinations and the number of reinfections during the period of observation.
在一项多中心随机双盲研究中，284例慢性化脓性鼻窦炎患者除接受标准治疗（抗生素、黏液溶解剂、吸入剂）外，还接受了口服免疫刺激剂或安慰剂治疗。治疗持续三个月，分三个连续的十天疗程。在开始治疗时、治疗期间以及六个月后，根据评分系统评估症状，并对鼻窦X线片进行评估。在治疗过程和随访期间，与安慰剂组相比，免疫刺激剂组主要症状头痛、脓性鼻涕、咳嗽和咳痰的改善具有统计学意义，X线检查和观察期内再次感染的次数提供了客观证据。
