Mao Xiaowei, Liu Ting, Bi Jiahai, Luo Li, Tian Demei, Li Haibing
Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China.
Chem Commun (Camb). 2016 Mar 21;52(23):4385-8. doi: 10.1039/c6cc00949b.
As complex organisms vary in vivo, it remains a challenging task to get fluorescence 'turn on' imaging for special targets. To address this task, we have adopted a new strategy of inducing pillararene based host-guest interactions onto biocompatible graphene. By means of fluorescence competition displacement, hydrazino-pillar[5]arene modified graphene has been synthesized and provided as a 'turn on' probe for paraquat through monitoring of the fluorescence signal both in living cells and mice.
由于复杂生物体在体内存在差异，对特殊靶点进行荧光“开启”成像仍然是一项具有挑战性的任务。为了解决这一任务，我们采用了一种新策略，即在生物相容性石墨烯上诱导基于柱芳烃的主客体相互作用。通过荧光竞争置换，合成了肼基柱[5]芳烃修饰的石墨烯，并通过监测活细胞和小鼠体内的荧光信号，将其作为百草枯的“开启”探针。
