分辨率为1.9埃的4锌牛胰岛素晶体结构测定。
Crystal structure determination of 4-zinc bovine insulin at 1.9 A resolution.
作者信息
Li M, Wang D C, Liang D C
机构信息
Institute of Biophysics, Academia Sinica, Beijing, PRC.
出版信息
Sci China B. 1989 Nov;32(11):1308-17.
PMID:2692596
Abstract
With the isomorphous difference Fourier method and the restrained least-squares refinement technique, the crystal structure of 4-zinc bovine insulin in space group R3 was determined. The final crystallographic residual is 0.19 at 1.9 A resolution. Based on the refined model, the structural mechanism for prolonged action of 4-zinc insulin is discussed.
摘要
利用同晶型差分傅里叶方法和约束最小二乘精修技术，确定了空间群R3中4-锌牛胰岛素的晶体结构。在1.9埃分辨率下，最终的晶体学残余因子为0.19。基于精修模型，讨论了4-锌胰岛素长效作用的结构机制。
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